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首页> 外文期刊>Advances in urology >Experience with Renal Autotransplantation: Typical and Atypical Indications
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Experience with Renal Autotransplantation: Typical and Atypical Indications

机译:肾自体移植的经验:典型和非典型适应症

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Introduction and Objectives. Renal autotransplantation is a kidney-saving surgical procedure used in selected patients. The purpose of this report is to review nine typical and atypical indications for kidney autotransplantation and evaluate its effectiveness in maintaining kidney function and avoiding cancer recurrence. Materials and Methods. From 1999 till 2014, nine renal autotransplantations were performed in our center. A retrospective case review was done. Four of nine patients had a solitary functioning kidney. Typical indications for autotransplantation included extended ureteric disease in 5 patients, intrasinusal tumor on a solitary kidney in 1 patient, and renal artery aneurysm in 1 patient. Atypical indications consisted in bilateral urothelial tumors in 1 patient and interrupted live kidney transplantation in 1 patient. Mean cold ischemia time was 209 minutes. Demographic factors, indications, renal function before and after surgery, and in the long term, cancer recurrence and disease-free survival were evaluated. Results. Renal function was maintained in 8 patients during the early follow-up. No serious complications occurred in the postoperative period. Median duration of follow-up was 50 months. In 4 patients with a normal contralateral kidney, mean preoperative and at discharge creatinine clearance were 105.45?ml/min and 121.02?ml/min, respectively. Although values showed an improvement in the kidney function, the difference was not significant ( value 0.3). In the other 4 patients with a solitary kidney, mean discharge creatinine clearance was 99.24?ml/min surprisingly higher than the preoperative value 96.92?ml/min. At the last follow-up, kidney function was preserved for the two groups (normal contralateral kidney/solitary kidney) with relatively stable creatinine clearance values 108.45?ml/min and 85.9?ml/min, respectively. No patients required secondary dialysis. Conclusion. Renal autotransplantation is a rare, safe, and effective surgical procedure for the treatment of complex urologic conditions. In some instances, it may be of great utility for kidney salvage in some carefully selected patients.
机译:简介和目标。肾脏自体移植是一种用于部分患者的节省肾脏的外科手术。这份报告的目的是回顾肾脏自体移植的九种典型和非典型适应症,并评估其在维持肾脏功能和避免癌症复发方面的有效性。材料和方法。从1999年到2014年,我们的中心进行了9次肾脏自体移植。回顾性病例进行了审查。 9例患者中有4例具有孤立的肾功能。自体移植的典型适应症包括5例输尿管疾病,1例孤立肾上的鼻窦内肿瘤和1例肾动脉瘤。非典型指征包括1例患者的双侧尿路上皮肿瘤和1例患者的活肾移植中断。平均冷缺血时间为209分钟。评估了人口统计学因素,适应症,术前和术后的肾功能,并长期评估了癌症的复发率和无病生存期。结果。在早期随访中,有8例患者保持了肾功能。术后无严重并发症发生。中位随访时间为50个月。对侧肾脏正常的4例患者术前和出院时的肌酐清除率分别为105.45?ml / min和121.02?ml / min。尽管数值显示肾脏功能有所改善,但差异并不显着(数值0.3)。在其他4例患有孤立肾的患者中,平均肌酐清除率是99.24?ml / min,出乎意料地高于术前值96.92?ml / min。在最后一次随访中,两组(正常对侧肾脏/孤立肾脏)的肾功能得以保持,肌酐清除率分别相对稳定,分别为108.45?ml / min和85.9?ml / min。没有患者需要二次透析。结论。肾脏自体移植是一种用于治疗复杂泌尿科疾病的罕见,安全且有效的手术方法。在某些情况下,它对于某些经过精心挑选的患者的肾脏挽救可能很有用。

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