Magnetic Hyperthermia Behavior of Electrospun Polyvinylpyrrolidone (PVP) Nanofibers Containing Magnetic Oxide Materials

摘要

Electromagnetic hyperthermia has been attracting significant attention in treating cancerous cells due to its non-invasive and quick recovery time. In this work, polyvinylpyrrolidone (PVP)solutions containing magnetic materials were used to make nanofibers through electrospinning. Transition metal oxides including cobalt oxide and iron oxide were selected as the magnetic responsive materials. The electrospun magnetic materials containing nanofibers were tested through the exposure to an external electromagnetic field to examine the increase in temperatures. It is found that the temperatures of the nanofibers increased high enough (above 43°C) to damage or eliminate cancer cells within 25 seconds. Comparisons of the hyperthermia behaviors of variousoxideswere studied as well.