Highly Sensitive Electrochemical Sensor for Anticancer Drug by aZirconia Nanoparticle-Decorated Reduced Graphene OxideNanocomposite

摘要

Because of their large surface area and conductivity, some inorganicmaterials have emerged as good candidates for the trace-level detection ofpharmaceutical drugs. In the present work, we demonstrate the detection of ananticancer drug (regorafenib, REG) by using an electrochemical sensor based on ananocomposite material. We synthesized a zirconia-nanoparticle-decorated reducedgraphene oxide composite (ZrO2/rGO) using a one-pot hydrothermal method.Reduction of the graphene oxide supports of the Zr2+ ions with hydrazine hydratehelped in preventing the agglomeration of the zirconia nanoparticles and in obtainingan excellent electrocatalytic response of the nanostructure ZrO2/rGO-basedelectrochemical sensor. Structural and morphological characterization of thenanostructure ZrO2/rGO was performed using various analytical methods. A novelregorafenib (REG) electrochemical sensor was fabricated by immobilizing the asprepared nanostructure ZrO2/rGO on to a glassy carbon electrode (GCE). Theresulting ZrO2/rGO/GCE could be used for the rapid and selective determination ofREG in the presence of ascorbic acid and uric acid. The ZrO2/rGO/GCE showed a linear response for the REG analysis in thedynamic range 11?343 nM, with a remarkable lower detection limit and limit of quantifications of 17 and 59 nM, respectively.The newly developed sensor was used for the accurate determination of REG in both serum samples and pharmaceuticalformulations, with satisfactory results.