Efficient New Protocols for Converting Primary Amides into Nitriles Initiated by P(NMe₂)₃, PCl₃, or P(OPh)₃

摘要

Three efficient and high-yielding procedures have been developed for the conversion of primary amides into nitriles, mediated by hitherto unexplored P(NMe_(2))_(3), PCl_(3), or P(OPh)_(3). The reactions were conducted under operationally simple and mild conditions and displayed broad substrate scope and good functional group tolerance.