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Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017)

机译:纳米粒子的生物相容性:金纳米棒对红细胞的血液学影响:溶血和血红蛋白的构象和功能变化(Adv。Sci。12/2017)

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Abstract In article 1700296 , Qunfang Zhou and co-workers report the hemocompatibility of gold nanorods (GNRs). In contrast to negatively charged GNRs, positively charged GNRs (C-GNRs) induce instant hemolysis. After cellular encapsulation, the GNRs are found to bind with hemoglobin and to induce conformational and functional changes in the protein. This demonstrates that surface modification holds great promise as an approach to improve the biocompatibility of GNRs for clinical use.
机译:摘要在1700296号文章中,周群芳及其同事报告了金纳米棒(GNR)的血液相容性。与带负电荷的GNR相比,带正电荷的GNR(C-GNR)引起即时溶血。细胞封装后,发现GNR与血红蛋白结合并诱导蛋白质的构象和功能变化。这表明表面修饰作为改善临床应用GNRs生物相容性的方法具有广阔的前景。

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