Photorefractive Keratectomy With Mitomycin-C for High Myopia: Three Year Follow-Up Results

摘要

Photorefractive keratectomy (PRK) is a safe and effective surgical keratorefractive techniquewhich is done with the application of mitomycin-C (MMC) in cases of high myopia to prevent the formationof corneal haze This study was conducted to evaluate 3-year visual acuity and quality outcomes of PRKMMCin high myopia. This before-after study was conducted on 20 individuals (40 eyes) with myopia morethan 6.0 diopter (D). Visual acuity and quality indices were evaluated before and three years after theprocedure and their stability was examined between the 1st and 3rd years. At 3 years after surgery, meanuncorrected visual acuity was 0.03±0.06 in the logarithm of minimum angle of resolution (logMAR) unitwhich showed a significant improvement when compared to baseline (P<0.001) and means best correctedvisual acuity was 0.03±0.06 logMAR, which showed no significant difference (P=0.730). Manifest refractionspherical equivalent (MRSE) at 3 years (-0.12±0.2D) was significantly decreased when compared to baseline(P<0.001), but it did not change significantly after the 1st year and was stable (P=0.368). Mean coma andspherical aberration 3 years postoperatively were -0.54±0.26 μm and 0.46±0.19 μm, respectively, and neitherparameter showed significant differences when compared to baseline (P<0.001). No significant change wasfound in mesopic contrast sensitivity. The long-term results of this study showed that PRK-MMC could beregarded an effective, safe, and stable procedure in patients with myopia more than 6.0 D.