Astragaloside IV Supplementation Promotes A Neuroprotective Effect in Experimental Models of Neurological Disorders: A Systematic Review

摘要

Background: Neurological disorders constitute a growing worldwide concern due to theprogressive aging of the population and the risky behavior they represent. Herbal medicines havescientific relevance in the treatment of these pathologies. One of these substances, Astragaloside IV(AS-IV), is the main active compound present in the root of Astragalus membranaceus (Fisch.)Bge, a Chinese medicinal herb with neuroprotective properties.Objective: In the present study we performed a systematic review that sought to comprehend theneuroprotective effect presented by AS-IV in experimental models of neurological disorders.Method: This study is a systematic review, where an electronic search in United States NationalLibrary of Medicine (PubMed), Science Direct, Cochrane Library, Scientific Electronic LibraryOnline (SciELO), Scopus, Web of Science, Medline via Proquest and Periodicos Capes databasescovering the years between 2007 and 2017, using “Astragaloside IV” and “Neurodegenerative dis-eases”; “Astragaloside IV” and “ Neurological disorders” as reference terms was made.Results: A total of 16 articles were identified, in which the efficacy of AS-IV was described in ex-perimental models of Parkinson’s disease, Alzheimer’s disease, cerebral ischemia and autoimmuneencephalomyelitis, by improving motor deficits and/or neurochemical activity, especially antioxi-dant systems, reducing inflammation and oxidative stress.Conclusion: The findings of the present study indicate that the administration of AS-IV can im-prove behavioral and neurochemical deficits largely due to its antioxidant, antiapoptotic and anti-inflammatory properties, emerging as an alternative therapeutic approach for the treatment of neu-rological disorders.