Two center experiences of Paget's disease of the breast in a sunny coastal city

摘要

SUMMARY Paget’s disease of the breast, is a rare disease of the breast which involves nipple and areola complex. There is often an underlying in situ or invasive breast cancer. This article compares and discuss information related to Paget’s disease of the breast obtained from the medical literature with the experience gained from cases followed in two seperate centers, in a southern costal city of Turkey, Antalya where there is a climate with abundant sun exposure most of the year. Sun exposure has been shown to be a modifiable risk factor for breast cancer and might play a role in the pathogenesis of Paget’s disease of the breast as well. This study aims to present clinicopathologic profiles of Paget’s disease patients from the city. Keywords: Paget’s disease of the breast, breast cancer, sun exposure, nipple and areola complex ?ZET Memenin Paget hastal??? meme ba?? ve areola kompleksini tutan memenin nadir g?rülen bir hastal???d?r. S?kl?kla altta yatan in situ veya invaziv meme kanseri birlikteli?ine rastlan?r. Bu makale, memenin Paget hastal??? hakk?nda literatürden derlenen bilgileri y?l?n büyük bir d?neminde havan?n olduk?a güne?li seyretti?i Türkiye’nin güney sahilinden bir ?ehirden, Antalya’dan, iki ayr? merkezde rastlan?lan vakalar ile elde edinilen deneyimi k?yaslayarak tart??may? hedeflemektedir. Güne?e maruziyet meme kanseri i?in müdahele edilebilen risk fakt?rlerinden oldu?u g?sterilmi?tir ve memenin Paget hastal???n?n patogenezinde rol oynuyor olabilir. ?al??ma, bu ?ehirdeki Paget hastalar?n?n klinikopatolojik profillerini sunmay? ama?lamaktad?r. Anahtar s?zcükler: Memenin Paget hastal???, meme kanseri, güne?e maruziyet, meme ba?? ve areola kompleksi