A generic concept for the development of model-guided clinical decision support systems

摘要

Disease development and progression are very complex processes which make clinical decision making non-trivial. On the one hand, examination results that are stored in multiple formats and data types in clinical information systems need to be considered. Beyond, biological or molecular-biological processes can influence clinical decision making. So far, biological knowledge and patient data is separated from each other. This complicates inclusion of all relevant knowledge and information into the decision making. In this paper, we describe a concept of model-based decision support that links knowledge about biological processes, treatment decisions and clinical data. It consists of three models: 1) a biological model, 2) a decision model encompassing medical knowledge about the treatment workflow and decision parameters, and 3) a patient data model generated from clinical data. Requirements and future steps for realizing the concept will be presented and it will be shown how the concept can support the clinical decision making.