Chemistry of 1,3-Dioxepins. X. Regio and Stereocontrolled Syntheses of Antihyperglycemic iN/i-Sulfonyl-1a,2,6,6a-tetrahydro-1iH/i,4iH/i[1,3] -dioxepino[5,6-ib/i]azirines ivia/i Isomeric icis/i- and itrans/i- Sulfonamidodioxepanols

摘要

Regio- and stereocontrolled syntheses of 1-sulfonyl-1a,2,6,6a-tetrahydro-1 H ,4 H [1,3] -dioxepino[5,6- b ]azirine 1, the lead compound of a novel class of potent antihyperglycemics, via isomeric cis - and trans -sulfonamidodioxepanols 6...