Reduction of Ketones with LiAlHsub4/sub Complexes of α,α,α',α'-Tetraaryl-1,3-dioxolane-4,5-dimethanols (TADDOLs) A Combination of Enantioselective Reduction and Clathrate Formation with a Discussion of LAH Reagents Bearing iC/isub2/sub-Symmetrical Ligands

摘要

A complex prepared from one equivalent each of LiAlH 4 , EtOH and a TADDOL (α,α,α',α'-tetraaryl-1,3-dioxolane-4,5-dimethanol) reduces aryl alkyl ketones to sec. alcohols with enantiomer ratios (er) up to 96 : 4. The chiral LAH...