RESEARCH: Zopiclone (Cyclopyrrolone): A Novel Hypnosedative; Hypnosedation Caused by Zopiclone Does Not Impair Memory‐Learning in Albino Mice

摘要

SUMMARY Objectives: To evaluate hypnosedative action of Zopiclone by using animal models for hypnosis and sedation (anxiolysis); and to further evaluate whether this hypnosedation impairs memory‐learning in albino mice like conventional hypnosedatives. Methods: For evaluation of hypnosedation, following experiments were performed in albino mice: (1) righting reflex test, (2) pentobarbitone sleeping time potentiation, (3) open field apparatus behavior, and (4) elevated plus maze performance. For evaluation of effects on impairment of memory‐learning, elevated plus maze retention test was performed in albino mice. Results: Zopiclone (7.5 mg/kg p.o.) did not inhibit the righting reflex. Significant ( P Conclusions: Zopiclone (7.5 mg/kg p.o.) has selective hypnosedative activity but not CNS‐depressant activity similar to BZDs. Hypnosedative action of Zopiclone does not impair memory‐learning in albino mice like conventional hypnosedatives.