Evaluating Postoperative Analgesics in Mice Using Telemetry

摘要

Thestudyexaminedtheefficacyofpreemptiveorpostoperativeanalgesiaonsurgicalpaininthemouse.Radiotelemetrytransmittersweresurgicallyimplantedin28femaleICRmice.Amockovaimplantationsurgerywasthenperformed.Miceweretreatedwithasingledoseofbuprenorphineorflunixinmegluminepriortooraftersurgery,threedosesofbuprenorphine,orwereuntreated.Heartrate,bloodpressure,homecageactivity,foodandwaterconsumption,andbodyweightweremeasured.Theno-analgesiagroupshowednosignificantdifferencesbetweenanyparameterscollectedpriortosurgeryandthosecollectedatsimilartimesduringthedayofsurgery.Significantincreasesinmouseactivityonthedayofsurgeryoccurredwithallanalgesictreatments,comparedwithpre-surgicalactivity.Therewerenoconsistentsignificantchangesinanyothertelemetryparameteraftertreatmentwithanalgesicscomparedwithnoanalgesia.Foodconsumptionandbodyweightthedayaftersurgerywerereducedsignificantlyintheanimalstreatedwiththreedosesofbuprenorphinecomparedwithuntreatedmiceandmicegivenasingledoseofbuprenorphine.Weconcludethatthemockovaimplantproceduredoesnotinducesufficientpaintocausealterationsinheartrateandbloodpressureinthemouse.Activitywassignificantlyreducedinthefirst6haftersurgeryinmicewithoutanalgesia,comparedwithactivitypriortosurgery.Therewerenosignificantdifferencesbetweenpre-emptiveandpostoperativeanalgesia.Bodyweightandfoodandwaterconsumptionwerepoormeasuresofpainbecauseanalgesiaaloneaffectedtheseparameters.