Background: "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. Aim: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. Methods: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. Results: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). Conclusion: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.
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机译：背景：“格雷夫斯眼病”（GO）是一种眼眶炎性疾病，涉及广泛的脂肪组织。从此类患者获得的眼眶脂肪的先前研究表明，脂联素基因和信使RNA过度表达。目的：与健康对照相比，此处报道的研究旨在测量GO患者的眼眶脂肪组织脂联素的蛋白质浓度。方法：这是一项前瞻性研究。通过酶联免疫吸附分析法分析了来自十名健康人的眼睑成形术和五名接受眼眶脂肪减压术治疗眼球突出症的GO患者的眼眶样本。结果：GO患者样品中的平均脂联素浓度为121.9±29.5 ng / mL（平均值±标准偏差），而对照组为107.9±26.6 ng / mL（P = 0.20）。结论：该研究无法证明两个研究组之间脂联素蛋白浓度的统计学差异。
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