TGF-1 Expression and Atrial Myocardium Fibrosis Increase in Atrial Fibrillation Secondary to Rheumatic Heart Disease

摘要

Background: Atrial fibrosis was considered a structural basis for the development and sustaining of atrial fibrillation (AF). Transforming growth factor-1 (TGF-1) was one of the main factors for accelerating collagen production. The contribution of TGF-1 in the pathogenesis of AF needs further investigation. Hypothesis: The altered expression and distribution of TGF-1 will be associated with the changes in atrial fibrosis in different types of AF patients with rheumatic heart disease (RHD). Methods: Right atrial specimens obtained from 38 RHD patients undergoing mitral valve replacement surgery were divided into 3 groups: the sinus rhythm group (n = 8), the paroxysmal AF group (pAF; n = 10), and the chronic AF group (cAF; AF lasting 6 mo; n = 20). The degree of atrial fibrosis, collagen content, serum levels, messenger RNA (mRNA), and protein expression of TGF-1 were detected. Results: The collagen content, serum level, TGF-1 mRNA, and protein expression of the atrial tissue increased gradually in sinus rhythm, for both pAF and cAF groups, respectively. A positive correlation between TGF-1 and the degree of atrial fibrosis was also demonstrated ( P 0.05). Conclusion: The TGF-1 expression in atrial tissue increased gradually in proportion to the degree of atrial fibrosis in AF and was associated with the type of AF, which suggests that TGF-1 is possibly involved in the pathogenesis of AF in RHD patients. Copyright ? 2010 Wiley Periodicals, Inc.