Detection of genetic predisposition in oral squamous cell carcinoma (OSCC) and oral submucous fibrosis patients by qualitative analysis of finger and palm-print patterns: A dermatoglyphic study

摘要

Introduction: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy and is a major cause of cancer morbidity and mortality worldwide. Oral submucous fibrosis (OSMF) is a potentially malignant condition and it affects approximately 0.5% (5 million) people of the population in the Indian subcontinent. The present study has been undertaken to evaluate the genetic predisposition and frequency of specific finger and palm-print patterns in OSCC and OSMF patients by dermatoglyphic analysis. Materials and Methods: Fingerprints of 400 individuals were recorded with the help of korex duplicating ink consisting of 100 normal individuals without habit of chewing or smoking tobacco or betel nut, 100 normal individuals with habit, 100 OSCC patients, and 100 OSMF patients. Result: We found that whorl type of fingerprint pattern was predominant in significantly higher number of individuals of OSCC and OSMF group than in control groups, whereas individuals of both the control groups showed loop as a predominant fingerprint pattern. This indicates that the predominance of whorl type of fingerprint pattern would serve as a candidate screening marker for susceptibility to oral squamous cell carcinoma and oral submucous fibrosis in general population with or without tobacco chewing habit.