Presumably Common Trigger Mechanism of Action of Diametrically Different Carcinogens on Target Cells

摘要

A large number of carcinogens and the wide spectrum of their actions may indicate their ability to trigger a common, general mechanism inside the normal biological program of somatic cells, which can lead to the development of the carcinogenic transformation of the normal cell. Numerous carcinogenic substances and factors of different natures probably can signify that these carcinogens must start up some common mechanism of normal cells transition into transformed states. Influence of physical, chemical, and biological carcinogenic agents on cells probably are adequate. By our opinion the common mechanism of action of diametrically different carcinogens on target-cells is the destruction of the plasmatic membrane. After influence of different carcinogens, cells’ fusion originates as a result of cytoplasmic membranes perforations (or modifications), i.e. formation in plasma membranes pores, what induces alteration of summary superficial charge of cells’ surface. Because of these, cells acquire ability to approach each other (adhesion), what in many cases may be a premise for fusion process. Thus, the initial target of carcinogenic agents is cells’ plasma membrane, but not the genetic apparatus of cells.