Serum lipid levels are multifactorial traits determined by a high number of genetic and environmental factors. The identification of the genetic component of this traits have been intensively investigated in the last years. These studies focused mainly on polymorphisms in genes coding for structural proteins and enzymes related to lipid metabolism. More recent studies showed that the effect of these polymorphisms depend in part on the interactions of different genotypes with classic risk factors like tabagism, overweight or physical inactivity. The variability observed in these genes seems to influence drug response of those commonly used in hyperlipidemia treatment.
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