The uses of ethyl 2-(1H-benzo[D]imidazol-2-yl)acetate to synthesis pyrazole, thiophene, pyridine and coumarin derivatives with antitumor activities

摘要

In the present work, the ethyl 2-(1 H -benzo[ d ]imidazol-2-yl)acetate ( 3 ) was subjected to a series of heterocyclization reactions through its reaction with different chemical reagents. The resulting molecules were thiophene, pyrazole, coumarin derivatives incorporated benzo[ d ]imidazole moiety. All the synthesized compounds were determined by elemental analysis, sup1/supH NMR, sup13/supC NMR, and MS. The antitumor evaluations of the newly synthesized products toward the three cancer cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer) showed that compounds 5a , 9b , 9c , 17 , 23b and 38 were of the highest potencies among the synthesized compounds.