Glucometry When Using Vitamin C in Sepsis: A Note of Caution

摘要

A recent before and after study in CHEST (June 2017) of IV vitamin C, thiamine, and hydrocortisone suggested a remarkable mortality benefit in patients with sepsis.sup1/sup A subsequent letter to the editor in CHEST (August 2017) raised a safety concern related to discrepancies between point of care (POC) and central laboratory glucose measurements when serum vitamin C concentrations are high.sup2/sup Different oxidation reactions are used by different POC devises to measure glucose. Vitamin C (and other molecules) can be oxidized by sensors and cause erroneous readings that are higher than actual serum glucose.