Synthesis of Novel Derivatives on the Basis of4-Hydrazinyl-6-methyl-2-(alkylthio)pyrimidines andTheir Preliminary Biological Evaluation

摘要

By functionalization of 4-hydrazinyl-6-methyl-2-(alkylthio)pyrimidines the corresponding acetohydrazides, N-phenylhydrazine-1-carboxamides(thioamides) were obtained. The heterocyclization of the same hydrazides lead to nonfused pyrazolyl-pyrimidines and pyridazinyl-pyrimidines and a series of 3-S-substituted derivatives of fused 1,2,4-triazolo[4,3-c]pyrimidine. The preliminary in vitro tests have shown that among the synthesized compounds there are substances exhibiting growth promoting properties.