1-Tosyl-2-trifluoroacetylindole as Promising Partner for Synthesis of Fused Fluorinated Heterocycles

摘要

We prepared 1-tosyl-2-trifluoroacetylindole - a novel example of an electron-deficient indole with an electrophilic C(3) position. This substance was involved in cyclocondensation with a variety of amidines to propose a new general pathway to 8H-[4,5-b]indolopyrimidines with yield 50-80%. CF_(3)-containing 5H-[3,2-d]indolopyrimidines were unknown before this study.