Study of the effect of surface modification of Fe 3 O 4 and CoFe 2 O 4 for application as a drug delivery

摘要

In this work, the obtention and characterization of Fe 3 O 4 and CoFe 2 O 4 associated to tetraethyl orthosilicate (TEOS) and 3-aminopropyltrimethoxysilane (APTS) were proposed, aiming to evaluate the effect of surface modification of magnetic particles on structural, morphological and magnetic properties for application as a drug carrier. The samples were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, textural analysis, scanning electron microscopy and magnetic measurements. The results showed that Fe 3 O 4 and CoFe 2 O 4 were synthesized successfully. The presence of the Fe 3 O 4 main phase was observed in the system obtained with Fe 3 O 4 /SiO 2 and CoFe 2 O 4 in the system obtained with CoFe 2 O 4 /SiO 2 . The formation of hybrids (core-shell) was confirmed by the presence of characteristic bands of silica. The systems obtained with Fe 3 O 4 had larger particle diameters than those formed with CoFe 2 O 4 , both formed by agglomerates of irregular size and shape and with typical behavior of ferrimagnetic materials.