Comparison of Permeability on the Actual and Ideal Cancellous Bone Microstructure

摘要

The synthesis of cancellous bone has a variety of factors to influence the design of trabecular bone including structure, material properties, geometry and permeability. To investigate such relationships, we used a constant flow rate permeameter to determine the intrinsic permeability of trabecular bone. The paper describes an analyses of actual and ideal model of microarchitecture and compares the corresponding permeability to find the similarity of cancellous bone structure that represents actual cancellous bone . In the present simulation, a computational fluid dynamics method was used to analyse fluid flow, the morphology of cancellous bone, the trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), bone volume fraction (BV.TV) and bone surface density (BS/BV). Three different models were analysed; actual model of cancellous bone, prismatic and quadratic crystal shape. The model geometry is 4.5 mm (diameter) and 4 mm (height). Fluid media in the simulation is blood, with a pressure of (15 kPa) and mass flow rate (100 ml/hr). The comparison of three model microstructure is also presented. The results show that prismatic model have similar permeability with actual model of cancellous bone. Quadratic crystal shape was the most grates permeability of cancellous bone .