Angioedema is a clinical condition characterized by transient edema in subcutaneous tissues such as lips, tongue, eye lids; intestinal wall; and upper respiratory tract causing asphyxia. It has been reported that some mechanisms related to cholin esterase 1 (C1) inhibitor may have a role in acquired angioedema. It is thought that, risperidone may suppress C1 esterase inhibitor, causing angioedema. The present case, 34 years old, married female, with a psychotic disorder diagnosis of postpartum period related is accepted to our clinic. Risperidon p.o 4 mg/day is started to the patient, who had used valproic asid for 2 years, due to her epileptic history. Valproic asid 1000 mg/day was added after moderately active epileptiform anomaly was observed in her EEG. The dose of risperidone was increased to 8 mg/day in time. After observing angioedema in the 2nd week of risperidone treatment of the patient, who has not any dermatological disorder before, risperidone treatment has stopped and antiedema treatment has started. The use of atypical antipsychotic drugs has enlarged in recent years. The treatment with atypical antipsychotic drugs has increased in not only psychotic disorders, but in also bipolar disorders, behavioral disturbances and anxiety disorders. There are only a few international case reports related to atypical antipsychotic drug risperidone causing angioedema. We aimed to draw clinicians attention to this dermatological adverse effect of the atypical antipsychotic drug risperidone.
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