Advanced nanofibrous textile-based dressing material for treating chronic wounds

摘要

In the present work, an electrospun nanofibrous textile composed of polyurethane (PU), sodium bicarbonate(NaHCO3) and pantothenic acid (PA) is developed for treating chronic wounds. Wounds are a common health problemand in particular, the chronic wounds such as vascular ulcers, diabetic ulcers and pressure ulcers cause a large number ofmorbidity and mortality. The main problems of the chronic wounds are prolonged inflammation phase and presence of acidicenvironment. These events deactivate the operation of growth factors and also the progression of natural healing mechanism.Hence, various types of advanced textile-based dressings are developed to address the clinical complications associated withchronic wound management. The prepared electrospun scaffolds were characterized to study their physicochemical andhaemocompatible properties. The scanning electron microscopy micrographs depicted continuous, smooth-interconnectednanofibrous morphology of PU–NaHCO$_3$–PA scaffolds. The Fourier transform infrared spectroscopy spectra indicatedthe addition of NaHCO$_3$ and PA-based hydrophilic chemical groups, which significantly enhanced the wettability of thecomposites. Further, the PU–NaHCO$_3$–PA composite membrane inferred to have a highly porous structure with the mean porosity of 79.4 $pm$ 4.8%, which may provide a conducive environment for adherence and proliferation of skin cells. The composite scaffold also offers a highly haemocompatible surface by delaying coagulation of blood through contact activationpathways and by limiting red blood cells damage. Therefore, the excellent physicochemical properties, blood compatibilityand the delivery of PA are anticipated to speed up the impaired healing process of chronic wounds.