首页> 外文期刊>BMC Pediatrics >A retrospective study of Human Immunodeficiency Virus transmission, mortality and loss to follow-up among infants in the first 18 months of life in a prevention of mother-to-child transmission programme in an urban hospital in KwaZulu-Natal, South Africa
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A retrospective study of Human Immunodeficiency Virus transmission, mortality and loss to follow-up among infants in the first 18 months of life in a prevention of mother-to-child transmission programme in an urban hospital in KwaZulu-Natal, South Africa

机译:南非夸祖鲁-纳塔尔省一家城市医院预防母婴传播计划中人类免疫缺陷病毒传播,死亡率和婴儿出生后前18个月的随访损失的回顾性研究。

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Background Follow up of Human Immunodeficiency Virus (HIV)-exposed infants is an important component of Prevention of Mother-to-Child Transmission (PMTCT) programmes in order to ascertain infant outcomes post delivery. We determined HIV transmission, mortality and loss to follow-up (LTFU) of HIV-exposed infants attending a postnatal clinic in an urban hospital in Durban, South Africa. Methods We conducted a retrospective cohort study of infants born to women in the PMTCT programme at McCord Hospital, where mothers paid a fee for service. Data were abstracted from patient records for live-born infants delivered between 1 May 2008 and 31 May 2009. The infants’ LTFU status and age was based on the date of the last visit. HIV transmission was calculated as a proportion of infants followed and tested at six weeks. Mortality rates were analyzed using Kaplan-Meier (K-M), with censoring on 15 January 2010, LTFU or death. Results Of 260 infants, 155 (59.6%) remained in care at McCord beyond 28 weeks: one died at? Conclusion This urban PMTCT programme achieved low transmission rates at six weeks, but LTFU in the first six months limited our ability to examine HIV transmission up to 18 months and determinants of mortality. The LTFU of infants born to women who attended antenatal care at 28 weeks gestation or later emphasizes the need to identify late antenatal attendees for follow up care to educate and support them regarding the importance of follow up care for themselves and their infants.
机译:背景暴露于人类免疫缺陷病毒(HIV)婴儿的随访是预防母婴传播(PMTCT)计划的重要组成部分,目的是确定分娩后的婴儿结局。我们确定了在南非德班的一家城市医院接受产后门诊治疗的HIV暴露婴儿的HIV传播,死亡率和随访损失(LTFU)。方法我们在McCord医院的PMTCT计划中对妇女出生的婴儿进行了回顾性队列研究,母亲为此支付了服务费。数据摘自2008年5月1日至2009年5月31日期间分娩的活产婴儿的患者记录。婴儿的LTFU状态和年龄基于上次就诊日期。 HIV的传播是按照婴儿的比例进行计算,并在六周时进行测试。使用Kaplan-Meier(K-M)分析死亡率,并于2010年1月15日对LTFU或死亡进行检查。结果麦考德医院共有260例婴儿在28周后仍接受护理,其中155例(59.6%):1例死亡。结论该城市PMTCT计划在六周内传播率较低,但是LTFU在最初的六个月中限制了我们检查长达18个月的HIV传播的能力以及死亡率的决定因素。在妊娠28周或更晚时接受产前护理的妇女所生婴儿的LTFU强调,需要确定晚期产前护理人员进行后续护理,以教育和支持他们对自己和婴儿进行后续护理的重要性。

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