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Prevalence and correlates of cognitive impairment in kidney transplant recipients

机译:肾移植受者认知障碍的患病率及其相关性

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Background There is a high prevalence of cognitive impairment in dialysis patients. The prevalence of cognitive impairment after kidney transplantation is unknown. Methods Study Design : Cross-sectional study . Setting and Participants : Single center study of prevalent kidney transplant recipients from a transplant clinic in a large academic center. Intervention : Assessment of cognition using the Montreal Cognitive Assessment (MoCA). Demographic and clinical variables associated with cognitive impairment were also examined. Outcomes and Measurements : a) Prevalence of cognitive impairment defined by a MoCA score of Results Data from 226 patients were analyzed. Mean (SD) age was 54 (13.4) years, 73% were white, 60% were male, 37% had diabetes, 58% had an education level of college or above, and the mean (SD) time since kidney transplant was 3.4 (4.1) years. The prevalence of cognitive impairment was 58.0%. Multivariable linear regression demonstrated that older age, male gender and absence of diabetes were associated with lower MoCA scores ( p Conclusion Cognitive impairment is common in prevalent kidney transplant recipients, at a younger age compared to general population, and is associated with certain demographic variables, but not level of eGFR.
机译:背景透析患者中​​认知障碍的患病率很高。肾移植后认知功能障碍的患病率尚不清楚。方法研究设计:横断面研究。设置和参与者:来自大型学术中心移植诊所的肾脏移植受者的单中心研究。干预:使用蒙特利尔认知评估(MoCA)进行认知评估。还检查了与认知障碍相关的人口统计学和临床​​变量。结果和测量:a)由MoCA结果评分定义的认知障碍患病率,分析了226例患者的数据。平均(SD)年龄为54(13.4)岁,白人为73%,男性为60%,糖尿病为37%,大专以上文化程度为58%,自肾移植以来的平均(SD)时间为3.4 (4.1)年。认知障碍的患病率为58.0%。多变量线性回归表明,年龄较大,男性性别和无糖尿病与较低的MoCA得分相关(p结论认知功能障碍在肾脏移植的普遍接受者中比较普遍,与普通人群相比年龄较小,并且与某些人口统计学变量有关,但不是eGFR级别。

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