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Trabecular coating on curved alumina substrates using a novel bioactive and strong glass-ceramic

机译:使用新型生物活性和强力玻璃陶瓷在弧形氧化铝基材上的小梁涂层

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In the last few years, optimal fixation of orthopaedicimplants evolved to preserve host bone andenhance tissue integration by surface modifications, includingthe use of coatings with bioactive ceramics. Inthis work, we fabricated a novel bone-like porous bioactiveglass-ceramic coating on curved alumina substrates;good joining between the two components was possibledue to the interposition of a glass-derived dense interlayer.The mechanical properties of the porous glass-ceramic,which mimics the 3-D pore architecture of cancellousbone, are adequate for load-bearing applications (compressivestrength of 19 MPa and fracture energy around6.5×10?4 J mm?3, with a total porosity of 62 vol.%). In vitrobioactive behaviour was investigated by testing the samplesin simulated body fluid and by evaluating the apatiteformation on the surface and pore struts of the trabecularcoating, which is a key precondition for in vivo osteointegration.The concepts disclosed in the present study couldfind interesting application in the context of orthopaedicimplants, with particular reference to full-ceramic acetabularcups for hip joint prosthesis.
机译:在过去的几年中,发展了对骨增生生物的最佳固定,以通过表面修饰,包括使用具有生物活性陶瓷的涂层,来保留宿主骨骼并增强组织整合。在这项工作中,我们在弯曲的氧化铝基材上制备了一种新型的骨状多孔生物活性玻璃陶瓷涂层;由于插入了玻璃衍生的致密中间层,因此两种成分之间可能实现良好的结合。多孔玻璃陶瓷的机械性能模仿松质骨的3-D孔结构,足以用于承重应用(抗压强度为19 MPa,断裂能约为6.5×10-4 J·mm-3,总孔隙率为62 vol。%)。通过在模拟体液中测试样品并评估小梁涂层的表面和孔撑上的磷灰石形成来研究其体外生物活性,这是体内骨整合的关键前提。本研究中公开的概念可能会在上下文中找到有趣的应用骨增生药的种类,特别是髋关节假体的全陶瓷髋臼杯。

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