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首页> 外文期刊>Brazilian Journal of Infectious Diseases >In vitro activities of antifungal agents alone and in combination against fluconazole-susceptible and -resistant strains of Candida dubliniensis
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In vitro activities of antifungal agents alone and in combination against fluconazole-susceptible and -resistant strains of Candida dubliniensis

机译:单独和联合使用抗真菌剂对氟康唑敏感和耐药的念珠菌念珠菌的体外活性

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摘要

In the present study we used two groups of Candida dubliniensis strains: one containing fluconazole-susceptible clinical isolates and another containing fluconazole-resistant laboratory derivative from the former to examine the changes on susceptibility accompanying the development of resistance to fluconazole. Our findings confirmed the ability of C. dubliniensis isolates to become resistant to fluconazole and indicated that this resistance was crossed with ketoconazole, itraconazole, ravuconazole and terbinafine. We also tested combinations of terbinafine, amphotericin B, itraconazole and voriconazole against both groups of isolates in a checkerboard assay. Surprisingly, most combinations evidenced indifferent interactions, and the best synergism appeared when terbinafine and itraconazole were combined against the fluconazole-resistant group.
机译:在本研究中,我们使用了两组假丝酵母念珠菌菌株:一组含有对氟康唑敏感的临床分离株,另一组含有前者对氟康唑的耐药性实验室衍生物,以检查随着对氟康唑耐药性的发展,药敏性的变化。我们的发现证实了杜氏梭菌对氟康唑的耐药性,并表明该耐药性与酮康唑,伊曲康唑,拉伏康唑和特比萘芬交叉耐药。我们还在棋盘检测中针对两组分离物测试了特比萘芬,两性霉素B,伊曲康唑和伏立康唑的组合。出乎意料的是,大多数组合显示出互不相同的相互作用,并且当特比萘芬和伊曲康唑联合抗氟康唑耐药组时,出现了最佳的协同作用。

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