Prognostic value of serum CYFRA 21-1 1 in patients with anal canal squamous cell carcinoma treated with radio(chemo)therapy

摘要

We aimed to assess the prognostic value of CYFRA 21-1 in a series of patients with anal canal squamous cell carcinoma treated by radiation-based therapy. All patients with anal cancer referred between September 2005 and July 2013 were considered. Patients with diagnosis of anal squamous cell carcinoma and in whom pre- and post-treatment serum CYFRA 21-1 levels were available were included. Serum CYFRA 21-1 levels at initial workup and after therapy were collected. Survival rates were estimated using the Kaplan–Meier method. Cox regression analysis was used to evaluate prognostic variables for prediction of outcomes. Eighty-two patients were included. Median follow-up was 60?months (range: 8–128). Pre-treatment serum CYFRA 21-1 levels were significantly correlated with tumour stage (p?