Abstract It has been recognized that tissue engineering and regenerative medicine (TERM) offers the next generation technology for whole organ and tissue transplantation for diseased, failed or malfunctioned organs. Biomaterials might be the one of the important factors to apply the complete bio-organ using {TERM} techniques. Around 30 years ago, the primitive concept of “Gradient Surface” had been introduced to improve the biocompatibility for biomaterials. However, the gradient concept of surface property is changing now numerous kinds of physicochemical properties very recently. In this review, the importance of the concept of gradient, the historical evolution of experimental methodology for the manufacturing of gradient surface during last over ~30 years in my research group and finally perspective as enabling technologies for the {TERM} area are summarized.
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