Asymmetric Mach–Zehnder Interferometer Based Biosensors for Aflatoxin M1 Detection

摘要

In this work, we present a study of Aflatoxin M1 detection by photonic biosensors based on Si 3 N 4 Asymmetric Mach–Zehnder Interferometer (aMZI) functionalized with antibodies fragments (Fab′). We measured a best volumetric sensitivity of 10 4 rad/RIU, leading to a Limit of Detection below 5 × 10 ?7 RIU. On sensors functionalized with Fab′, we performed specific and non-specific sensing measurements at various toxin concentrations. Reproducibility of the measurements and re-usability of the sensor were also investigated.