THE ROLE OF GLOMERULOSCLEROSIS AND TUBULAR ATROPHY AS DETERMINING FACTOR FOR REDUCED KIDNEY FUNCTION IN KIDNEY STONE DISEASE

摘要

Background: Kidney fibrosis including glomerulosclerosis (GS) and tubulointerstitial fibrosis (TIF)or tubular atrophy (TA) may be predictor of kidney dysfunction. Estimated glomerular filtration rate(eGFR) is a common laboratory examination to estimate the kidney function. The aim of this researchis to determine relationship between histologic features namely glomerulosclerosis (GS) and tubularatrophy (TA), and estimated glomerular filtration rate (eGFR) in kidney stone disease. Methods: Across-sectional study in a total of the 63 patients with kidney stone consisted of 25 (39.7 %) males and38 (60.3 %) females, aged (51 ± 11 years), Blood urea nitrogen (BUN) 16 (8-62) mg/dl, serumcreatinine 1.26 ( 0.47- 6.76 ) mg/dl and eGFR 61.4 ± 32.1 ml/min. Histologic features showed GSindex 6 (0-30) and TA index 892 ± 333. There was significant correlation between eGFR and GSindex dan TA index(r -0,577; p=0.001 and 0,514;p = 0,001, consecutively). Multivariate regresionequations were eLFG = 67,21 -1.63 (GS index) and eLFG = 67,21 + 0,01 (TA index). Estimated GFRmay be used as a marker of glomerulosclerosis and tubular atrophy in obstructive nephropathy ofkidney stone patients.