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首页> 外文期刊>Bioengineering >Trinity of Three-Dimensional (3D) Scaffold, Vibration, and 3D Printing on Cell Culture Application: A Systematic Review and Indicating Future Direction
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Trinity of Three-Dimensional (3D) Scaffold, Vibration, and 3D Printing on Cell Culture Application: A Systematic Review and Indicating Future Direction

机译:三维(3D)支架,振动和3D打印在细胞培养应用上的三位一体:系统评价和指示未来方向

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摘要

Cell culture and cell scaffold engineering have previously developed in two directions. First can be ‘static into dynamic’, with proven effects that dynamic cultures have benefits over static ones. Researches in this direction have used several mechanical means, like external vibrators or shakers, to approximate the dynamic environments in real tissue, though such approaches could only partly address the issue. Second, can be ‘2D into 3D’, that is, artificially created three-dimensional (3D) passive (also called ‘static’) scaffolds have been utilized for 3D cell culture, helping external culturing conditions mimic real tissue 3D environments in a better way as compared with traditional two-dimensional (2D) culturing. In terms of the fabrication of 3D scaffolds, 3D printing (3DP) has witnessed its high popularity in recent years with ascending applicability, and this tendency might continue to grow along with the rapid development in scaffold engineering. In this review, we first introduce cell culturing, then focus 3D cell culture scaffold, vibration stimulation for dynamic culture, and 3DP technologies fabricating 3D scaffold. Potential interconnection of these realms will be analyzed, as well as the limitations of current 3D scaffold and vibration mechanisms. In the recommendation part, further discussion on future scaffold engineering regarding 3D vibratory scaffold will be addressed, indicating 3DP as a positive bridging technology for future scaffold with integrated and localized vibratory functions.
机译:细胞培养和细胞支架工程以前已经在两个方向发展。首先可以是“从静态转变为动态”,事实证明,动态文化比静态文化更具优势。在这个方向上的研究已经使用了几种机械手段,例如外部振动器或振动器,来近似真实组织中的动态环境,尽管这种方法只能部分解决这个问题。其次,可以将“ 2D转换为3D”,也就是说,已经将人工创建的三维(3D)被动(也称为“静态”)支架用于3D细胞培养,从而帮助外部培养条件更好地模拟了真实组织的3D环境。与传统的二维(2D)培养相比。在3D支架的制造方面,近年来3D打印(3DP)随着其适用性的提高而受到广泛欢迎,并且随着支架工程的快速发展,这种趋势可能会继续增长。在这篇综述中,我们首先介绍细胞培养,然后重点介绍3D细胞培养支架,用于动态培养的振动刺激以及制造3D支架的3DP技术。将分析这些领域的潜在相互联系,以及当前3D支架和振动机制的局限性。在推荐部分中,将讨论有关3D振动脚手架的未来脚手架工程的进一步讨论,表明3DP作为具有集成和局部振动功能的未来脚手架的积极桥接技术。

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