Editorial

摘要

This issue of CDR contains a range of interesting, well-crafted and insightful reviews on diabetes mellitus and itsncomplications by highly respected groups of investigators. At the level of the pancreatic acinar cells, Bouwens examines thenability of beta cells to regenerate, and considers recent data such as the use of combinations of growth factors to promotenregeneration or replacement by precursor cell neogenesis, which may eventually contribute to a therapeutic approach to insulindependentndiabetes. Kim et al. reviews research on the transcriptional regulation of glucose sensors (GLUT2 and glucokinase)nin beta cells and liver and the potential role for these mechanisms in the development of insulin resistance in type 2 diabetes.