Synthetic Modifications of Ascomycin.V.Access to Novel Ascomycin Derivatives by Replacement of the Cyclohexylvinylidene Subunit

Reinhold Zimmer; Karl Baumann; Hildegard Sperner; Gerhard Schulz; Ewald Haidl; Maximilian A.Grassberger

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Synthetic Modifications of Ascomycin.V.Access to Novel Ascomycin Derivatives by Replacement of the Cyclohexylvinylidene Subunit

机译：Ascomycin.V的合成修饰。通过取代环己基亚乙烯基亚基获得新型Ascomycin衍生物

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摘要

Starting from the easily accessible 24-0-tert-butyldimethylsilyl-22(R)-dihydro-28-oxoascomy-cin,methodologies that allow replacement of the Cyclohexylvinylidene moiety of ascomycin by various other substituents are described.In addition,a so far unknown reactivity of the masked tricarbonyl moiety of ascomycin towards a stabilized Wittig reagent is reported.

机译：从容易获得的24-0-叔丁基二甲基甲硅烷基-22（R）-二氢-28-氧杂孢子霉素开始，描述了允许用各种其他取代基代替子囊霉素的环己基亚乙烯基部分的方法。此外，迄今为止未知报道了被纯化的子囊霉素的三羰基部分对稳定的Wittig试剂的反应性。

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来源
《Croatica Chemica Acta》 |2005年第1期|p.17-27|共11页
作者
Reinhold Zimmer; Karl Baumann; Hildegard Sperner; Gerhard Schulz; Ewald Haidl; Maximilian A.Grassberger;
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作者单位

Institut fur Chemie-Organische Chemie,Freie Uniuersitat Berlin,Takustrasse 3,D-4195 Berlin,Germany;

Novartis Forschungsinstitut,Brunner Strasse 59,A-I235 Wien,Austria;

Novartis Forschungsinstitut,Brunner Strasse 59,A-I235 Wien,Austria;

Novartis Forschungsinstitut,Brunner Strasse 59,A-I235 Wien,Austria;

Novartis Forschungsinstitut,Brunner Strasse 59,A-I235 Wien,Austria;

Novartis Forschungsinstitut,Brunner Strasse 59,A-I235 Wien,Austria;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类化学;
关键词
ascomycin; immunosuppressiva; aldol reaction; oxime; Wittig reaction; oxidation;

机译：子囊霉素;免疫抑制;醛缩反应;肟;维蒂希反应;氧化;

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专利

1. Synthetic modification of ascomycin:Part III~1-A concise transformation of iso-ascomycin to 19,20-seco-derivatives [J] . Reinhold Zimmer, Maximilian A Grassberger, Karl Baumann Indian Journal of Chemistry, Section B. Organic Including Medicinal . 1999,第7期

机译：子囊霉素的合成修饰：第III〜1-A部分将异子囊霉素转化为19,20-seco衍生物
2. SYNTHETIC MODIFICATIONS OF ASCOMYCIN .2. A SIMPLE AND EFFICIENT WAY TO MODIFIED ISO-ASCOMYCIN DERIVATIVES [J] . Zimmer R., Baumann K., Horvath A., Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 1995,第42期

机译：阿霉素的合成修饰.2。修改ISO-ASCOMYCIN衍生物的简便方法
3. New Derivatives of Ascomycin with Modifications in the Amino Acid Region - Synthesis and Biological Activities, and X-Ray Crystal Structure of 5,6-Dehydroascomycin [J] . Bulusu MARC, Waldstatten P, Tricotet T, Helvetica chimica acta . 2009,第5期

机译：在氨基酸区域有修饰的新霉素衍生物-5,6-脱氢霉素的合成，生物活性和X射线晶体结构
4. Hybrid Nanoparticles Prepared by In-situ and Post-synthetic Surface Modification of Lanthanide-Based Nanoparticles with Phosphonic Acid Derivatives [C] . Christoph Rill, Sorin Ivanovici, Guido Kickelbick Materials Research Society Symposium . 2008

机译：通过原位制备的杂合纳米粒子和用膦酸衍生物的基于镧系元素的纳米粒子制备的杂交纳米粒子
5. Post-translational modification of the large subunit (LS) and small subunit (SS) of Rubisco and the molecular utility of Rubisco LSMT to deliver carbonic anhydrase to the active site vicinity of Rubisco. [D] . Meier, Brent W. 2004

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6. Opening New Gates for the Modification of PVC or Other PVC Derivatives: Synthetic Strategies for the Covalent Binding of Molecules to PVC [O] . Rodrigo Navarro, Mónica Pérez Perrino, Carolina García, 2010

机译：为修饰PVC或其他PVC衍生物打开新的大门：分子与PVC共价结合的合成策略
7. An investigation on using pre-treated tyre rubber as a replacement of synthetic polymers for bitumen modification [O] . Subhy, Ayad, Lo Presti, Davide, Airey, Gordon 2015

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Synthetic Modifications of Ascomycin.V.Access to Novel Ascomycin Derivatives by Replacement of the Cyclohexylvinylidene Subunit

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