首页> 外文期刊>Coordination chemistry reviews >A versatile small-molecule fluorescence scaffold: Carbazole derivatives for bioimaging
【24h】

A versatile small-molecule fluorescence scaffold: Carbazole derivatives for bioimaging

机译:多功能的小分子荧光支架:用于生物成像的咔唑衍生物

获取原文
获取原文并翻译 | 示例
       

摘要

Carbazole derivatives have been receiving extensive attention owing to the merits of favorable donor ability, good planarity, rich photophysical properties, and excellent biocompatibility. In recent years, carbazole-based small molecular fluorescent probes have developed rapidly and extensively utilized for bioimaging, providing abundant and valuable information for studying important life processes. Although the topic of carbazole-based fluorescent probes for bioimaging is important and frontier, no review focused on this hot subject so far. Thus, in this tutorial review, we firstly summarize and highlight the recent advances in design, photophysical properties, and biological applications of carbazole-based probes. In order to legibly and intuitively grasp the topic, this work was classified into five parts according to the sensing targets detected by carbazole-based probes. Accordingly, we provide an overview of recent advances of carbazole derivatives for bioimaging in the perspective of biological applications of the carbazole chemosensors toward ionic species, reactive sulfur species (RSS), reactive oxygen species (ROS), biomacromolecules, microenvironment and others. Several representative examples for each bio-application have been reviewed, and all these cases demonstrate that carbazole derivatives could act as a robust tool for monitoring biomolecules in living systems. Moreover, with the assistance of fluorescence imaging, some carbazole-based probes can be employed to feedback the subtle concentration changes of biomarkers at the disease sites, greatly facilitating the significant advances in cell biology and medical diagnostic imaging. In addition, we also discuss the unsolved problems and future challenges in the terms of synthesis and biological application of carbazole derivatives. Future attention should be focused on the designing carbazole-based probes involving near-infrared emission and multiple sites to improve detection efficacy and provide more biological information. More importantly, great effort and collaboration from different communities of chemists, physicists and biologists are required to translating laboratory feasibility of carbazole derivatives to clinical practicability. This review herein will promote new progress and improvements of novel carbazole-based probes for further exploring life events. (C) 2020 Elsevier B.V. All rights reserved.
机译:咔唑衍生物由于其良好的供体能力,良好的平面性,丰富的光物理性质和优异的生物相容性而受到广泛关注。近年来,基于咔唑的小分子荧光探针已得到快速发展,并广泛用于生物成像,为研究重要的生命过程提供了丰富而有价值的信息。尽管基于咔唑的生物成像荧光探针主题很重要且很前沿,但到目前为止,尚无针对此热门主题的评论。因此,在本教程的复习中,我们首先总结并强调基于咔唑的探针在设计,光物理性质和生物学应用方面的最新进展。为了清晰,直观地理解该主题,根据咔唑基探针检测到的目标,将这项工作分为五个部分。因此,我们从咔唑化学传感器在离子种类,活性硫种类(RSS),活性氧种类(ROS),生物大分子,微环境等方面的生物学应用角度,概述了咔唑衍生物在生物成像中的最新进展。审查了每种生物应用的几个代表性实例,所有这些案例表明咔唑衍生物可以作为监测生命系统中生物分子的强大工具。此外,借助荧光成像,一些基于咔唑的探针可用于反馈疾病部位生物标志物的细微浓度变化,从而极大地促进了细胞生物学和医学诊断成像的重大进步。此外,我们还讨论了咔唑衍生物的合成和生物学应用方面尚未解决的问题和未来的挑战。未来的注意力应集中在设计基于咔唑的探针上,该探针涉及近红外发射和多个位点,以提高检测效率并提供更多的生物学信息。更重要的是,需要将化学家,物理学家和生物学家的不同社区共同努力,将咔唑衍生物的实验室可行性转化为临床实用性。本文的综述将促进基于咔唑的新型探针的新进展和改进,以进一步探索生命事件。 (C)2020 Elsevier B.V.保留所有权利。

著录项

  • 来源
    《Coordination chemistry reviews》 |2020年第6期|213257.1-213257.22|共22页
  • 作者

  • 作者单位

    Univ Jinan Inst Fluorescent Probes Biol Imaging Sch Chem & Chem Engn Sch Mat Sci & Engn Jinan 250022 Shandong Peoples R China;

    Univ Jinan Inst Fluorescent Probes Biol Imaging Sch Chem & Chem Engn Sch Mat Sci & Engn Jinan 250022 Shandong Peoples R China|Guangxi Univ Sch Chem & Chem Engn Inst Opt Mat & Chem Biol Nanning 530004 Guangxi Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Carbazole derivatives; Bioimaging; Fluorescence; Reactive sulfur species; Reactive oxygen species; Biomacromolecules; Microenvironment;

    机译:咔唑衍生物;生物成像荧光;活性硫种类;活性氧;生物大分子;微环境;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号