Organocatalytic and metal-mediated asymmetric [3 + 2] cycloaddition reactions

摘要

This review focuses on recent progress in organocatalytic and metal-mediated asymmetric [3 + 2] cycloadditions, including 'click' chemistry, asymmetric 1,3-dipolar and asymmetric non-1,3-dipolar [3 + 2] cycloadditions.The theoretical aspects and synthetic applications of these organocatalytic and metal-mediated asymmetric [3 + 2] cycloadditions are summarized.In addition, an understanding of the mechanistic details which lead to efficient stereoselectivity in organocatalytic and metal-mediated asymmetric [3 + 2] cycloadditions is provided.Most of the references reviewed in this paper are from 2007 upto now.