Novel nutraceutical Myricetin composite of enhanced dissolution obtained by co-crystallization with acetamide

摘要

In order to improve the physicochemical properties and solubility of the nutraceutical compound Myricetin, we investigated its propensity to form co-crystals with acetamide. A novel co-crystal was obtained by solvent drop grinding of Myricetin and acetamide. The co-crystal formation was evidenced by X-ray powder diffraction, thermal analysis and spectroscopic techniques (FT-IR, H-1 MAS NMR). Stability study on exposure to elevated temperature and relative high humidity indicated that the co-crystal change to Myricetin form within 8 weeks. On the other hand, solubility and dissolution measurements showed a 4 times increase in the dissolution rate of the co-crystal in water compared to Myricetin. Our study shows that the co-crystal of Myricetin with acetamide could be a candidate for developing solid oral dosage formulations of enhanced bioavailability. (C) 2015 Elsevier Ltd. All rights reserved.