Editorial [Hot Topic:Supramolecular Devices for the High-Throughput Screening of Drugs,Nutrients and Metabolites in Postgenomic Era (Part 2)(Guest Editor: Grzegorz Bazylak)]

摘要

Instrumentation-based HTS and μHTS is being improved by introducing nanolitre devices for dispensing fluids with extraordinary precision and biosensor-chip based multimode ultra-high sensitive readout protocols both of which are compatible with high density microwell and multiplate formats. A wide range of catalytic and affinity-based sensing elements together with variable fluorescence detection technologies have been implemented successfully into HTS which shifted the focus from observing macroscopic intermolecular events to the nanoscale, supramolecular and even single molecular level. In this way, HTS assays for drug discovery have developed information-rich, multiparameter readout systems for diverse molecular and supramolecular data that can include internal quality controls such as real-time feedback, self-diagnosis and adaptive supervising. These capabilities can reduce false-positive or false-negative rates caused by non-specific binding, degradation, precipitation, evaporation, poor solubility, or viscosity related sub-optimal concentration. Some of these emerging concepts and challenges for HTS are discussed in this issue of Combinatorial Chemistry & High Throughput Screening, which is Part 2 of a special issue commemorating the beginning of supramolecular chemistry in 1967.