Sample-to-Sample Carryover is Insignificant when Sharing Serum Samples between ADVIA~® Chemistry Systems and ADVIA Centaur~® Immunoassay Systems

摘要

This study demonstrates that clinically significant sample-to-sample carryover is not detectable between AD-VIA Chemistry Systems and ADVIA Immunoassay Systems using samples with artificially elevated concentrations of hCG, HIV, HBsAg or HCV. The ADVIA 1650 Chemistry System's positive displacement sampling system with the integrated analyzer washing system is efficient in preventing sample-to-sample carryover in samples with high levels of infectious disease markers or tumor markers. With these highly sensitive assays, and when using samples in concentrations that would normally be found in clinical laboratories, significant sample-to-sample carryover is non-detectable on the ADVIA Centaur immunoassay tests subsequently performed after sampling on the ADVIA 1650 Chemistry System. These findings of insignificant carryover with clinical specimens will allow the laboratory to safely share samples between Bayer's chemistry systems and immunoas-say systems in the laboratory without making separate aliquots for each system. Additionally, the laboratory can have the choice of whether to run the samples first on the ADVIA Centaur system, first on the ADVIA 1650 system, or a mixture of both methods, depending on the needs and turn-around requirements for each laboratory. With our laboratory automation solutions, the ADVIA WorkCell or the ADVIA LabCell, each site can set different priorities by test in the software tables.