Prospective, Randomized Inpatient Study of Oral Metronidazole versus Oral Metronidazole and Rifampin for Treatment of Primary Episode of Clostridium difficile–Associated Diarrhea

摘要

Background. To date, no randomized trial to address the use of adjunctive rifampin in addition to metronidazole for the treatment of Clostridium difficile–associated diarrhea has been reported. Rifampin has excellent in vitro activity against C. difficile and penetrates into cellular materials where the organisms may persist.