Characterization of thyroglobulin epitopes in Sardinian adults and juveniles with Hashimoto’s thyroiditis: evidence against a major effect of age and genetic background on B-cell epitopes

Francesco Latrofa; Debora Ricci; Paolo Vitti; Alessia Prinzis; Valentina Maria Cambuli; Mariangela Ghiani; Sabrina Pilia; Daniela Carta; Sandro Loche; Aldo Pinchera; Stefano Mariotti

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Characterization of thyroglobulin epitopes in Sardinian adults and juveniles with Hashimoto’s thyroiditis: evidence against a major effect of age and genetic background on B-cell epitopes

机译：桥本甲状腺炎在撒丁岛成年人和青少年中甲状腺球蛋白表位的表征：证据表明年龄和遗传背景对B细胞表位有重大影响

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Background Using recombinant human monoclonal thyroglobulin antibodies expressed as Fab molecules (TgAb-Fab), we have recently confirmed the restriction of Tg epitopes in Hashimoto’s thyroiditis (HT).

机译：背景技术最近，我们使用表达为Fab分子的重组人单克隆甲状腺球蛋白抗体（TgAb-Fab），证实了桥本甲状腺炎（HT）中Tg表位的限制。

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《Clinical Endocrinology》 |2010年第1期|110-113|共4页
作者
Francesco Latrofa; Debora Ricci; Paolo Vitti; Alessia Prinzis; Valentina Maria Cambuli; Mariangela Ghiani; Sabrina Pilia; Daniela Carta; Sandro Loche; Aldo Pinchera; Stefano Mariotti;
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Department of Endocrinology WHO Collaborating Centre for the Diagnosis and Treatment of Thyroid Cancer and Other Thyroid Diseases University of Pisa;

Endocrinology Department of Medical Sciences AmbiSEN Center University of Cagliari;

Paediatric Endocrine Unit Regional Hospital for Microcitaemia Cagliari Italy;

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1. Characterization of thyreoglobulin epitopes in Sardinian adults and juveniles with Hashimoto's thyroiditis: evidence against a major effect of age and genetic background on B-cell epitopes [J] . Francesco Latrofa, Debora Ricci, Paolo Vitti, Clinical Endocrinology . 2010,第1期

机译：桥本甲状腺炎在撒丁岛成年人和青少年中甲状腺球蛋白表位的表征：证据表明年龄和遗传背景对B细胞表位有重大影响
2. Evidence of a Combined Cytotoxic Thyroglobulin and Thyroperoxidase Epitope-Specific Cellular Immunity in Hashimoto's Thyroiditis [J] . Margret Ehlers, Annette Thiel, Christian Bernecker, The journal of clinical endocrinology and metabolism . 2012,第4期

机译：桥本甲状腺炎合并细胞毒性甲状腺球蛋白和甲状腺过氧化物酶抗原决定簇特异性细胞免疫的证据
3. Epitope recognition patterns of thyroglobulin antibody in sera from patients with Hashimoto's thyroiditis on different thyroid functional status [J] . LiuM., ZhaoL., GaoY., Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology . 2012,第3期

机译：不同甲状腺功能状态桥本甲状腺炎患者血清甲状腺球蛋白抗体的抗原表位识别模式
4. Genetic manipulation with the T-cell receptor (TCR) and major histocompatibility complex (MHC) binding sites of arthritogenic epitopes of the G1 domain of human aggrecan. [D] . Murad, Yanal Muhammad. 2005

机译：人类聚集蛋白聚糖G1结构域的关节炎形成抗原决定簇的T细胞受体（TCR）和主要组织相容性复合体（MHC）结合位点的遗传操纵。
5. Antibodies against Proinsulin and Homologous MAP Epitopes Are Detectable in Hashimoto’s Thyroiditis Sardinian Patients an Additional Link of Association [O] . Magdalena Niegowska, Daniela Paccagnini, Carlo Burrai, -1

机译：在桥本的甲状腺炎撒丁岛患者中可检测到针对胰岛素原和同源MAP表位的抗体
6. Antibodies against Proinsulin and Homologous MAP Epitopes Are Detectable in Hashimoto's Thyroiditis Sardinian Patients, an Additional Link of Association. [O] . Magdalena Niegowska, Daniela Paccagnini, Carlo Burrai, 2015

机译：针对胰岛素原和同源map表位的抗体在桥本氏甲状腺炎患者中是可检测的，这是一种额外的关联联系。

Characterization of thyroglobulin epitopes in Sardinian adults and juveniles with Hashimoto’s thyroiditis: evidence against a major effect of age and genetic background on B-cell epitopes

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