A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (ChronocortTM) vs. conventional hydrocortisone (CortefTM) in the treatment of congenital adrenal hyperplasia

Somya Verma; Carol VanRyzin; Ninet Sinaii; Mimi S. Kim; Lynnette K. Nieman; Shayna Ravindran; Karim A. Calis; Wiebke Arlt; Richard J. Ross; Deborah P. Merke

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A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (ChronocortTM) vs. conventional hydrocortisone (CortefTM) in the treatment of congenital adrenal hyperplasia

机译：缓释和缓释氢化可的松（Chronocort TM ）与常规氢化可的松（Cortef TM ）治疗先天性肾上腺皮质增生的药代动力学和药效学研究

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Objective Existing glucocorticoid treatment for congenital adrenal hyperplasia (CAH) is suboptimal and nonphysiological. We compared hormonal profiles during therapy with a new modified-release hydrocortisone (MR-HC), Chronocort?, to conventional hydrocortisone (HC), Cortef?, in patients with CAH.

机译：目的现有的糖皮质激素治疗先天性肾上腺皮质增生（CAH）效果欠佳且非生理性。我们比较了CAH患者使用新的缓释氢化可的松（MR-HC）Chronocort ？与常规氢化可的松（HC）Cortef ？治疗期间的激素状况。

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《Clinical Endocrinology》 |2010年第4期|441-447|共7页
作者
Somya Verma; Carol VanRyzin; Ninet Sinaii; Mimi S. Kim; Lynnette K. Nieman; Shayna Ravindran; Karim A. Calis; Wiebke Arlt; Richard J. Ross; Deborah P. Merke;
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Reproductive Biology and Medicine Branch The Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda MD USA;

National Institutes of Health Clinical Center Bethesda MD USA;

Section Endocrinology Diabetes Metabolism School of Clinical Experimental Medicine University of Birmingham Birmingham UK;

Academic Unit of Diabetes Endocrinology Metabolism School of Medicine Royal Hallamshire Hospital University of Sheffield Sheffield UK;

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1. A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (Chronocort~(TM)) vs. conventional hydrocortisone (Cortef~(TM)) in the treatment of congenital adrenal hyperplasia [J] . Somya Verma, Carol VanRyzin, Ninet Sinaii Clinical Endocrinology . 2010,第4期

机译：延迟和延长释放氢化可的松（Chronocort〜）与常规氢化可的松（Cortef〜）的药代动力学和药效学研究治疗先天性肾上腺皮质增生
2. Pharmacokinetic/pharmacodynamics analysis of hydrocortisone in pediatric patients with congenital adrenal hyperplasia [J] . Melin Johanna, Truong Thi, Hindmarsh Peter, Journal of pharmacokinetics and pharmacodynamics . 2016,第Suppla期

机译：氢化可的松在小儿先天性肾上腺皮质增生患者中的药代动力学/药效学分析
3. A model-based pharmacokinetic/pharmacodynamic analysis of hydrocortisone, 17-hydroxyprogesterone (17OHP), and androstenedione (D4A) in children with congenital adrenal hyperplasia (CAH) [J] . Ahmed M. A., Sarafoglou K., Al-Kofahi M., Journal of pharmacokinetics and pharmacodynamics . 2016,第Suppla期

机译：先天性肾上腺皮质增生（CAH）儿童中氢化可的松，17-羟基孕酮（17OHP）和雄烯二酮（D4A）的基于模型的药代动力学/药效学分析
4. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency A paradigm for prenatal diagnosis and treatment [C] . Saroj Nimkarn, Maria I. New Conference on Skeletal Biology and Medicine . 2010

机译：先天性肾上腺素增生由于21羟化酶缺乏症的产前诊断和治疗范式
5. Pharmacokinetic and pharmacodynamic studies of gamma-hydroxybutyric acid (GHB): Toxicity treatment and tolerance development. [D] . Bhattacharya, Indranil. 2006

机译：γ-羟基丁酸（GHB）的药代动力学和药效学研究：毒性治疗和耐受性发展。
6. A Pharmacokinetic and Pharmacodynamic Study of Delayed- and Extended-Release Hydrocortisone (Chronocort™) versus Conventional Hydrocortisone (Cortef™) in the Treatment of Congenital Adrenal Hyperplasia [O] . Somya Verma, Carol VanRyzin, Ninet Sinaii, -1

机译：延迟和延长释放氢化鞘（Chronocort TM）对常规氢化体（Cortef TM）治疗先天性肾上腺增生的药代动力学和药效学研究
7. A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (ChronocortTM)vs.conventional hydrocortisone (CortefTM) in the treatment of congenital adrenal hyperplasia [O] . Somya Verma, Carol VanRyzin, Ninet Sinaii, 2010

机译：延迟和延长释放氢化胞嘧啶（Chronocorttm）vs.Corpentional氢化胞苷（Corteftm）治疗先天性肾上腺增生的药代动力学和药效学研究

A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (ChronocortTM) vs. conventional hydrocortisone (CortefTM) in the treatment of congenital adrenal hyperplasia

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