The Parental Craniofacial Morphological Features in Chinese Patients With Sporadic Nonsyndromic Cleft Lip With or Without Palate

摘要

To evaluate the parental craniofacial morphology in Chinesenpatients with sporadic nonsyndromic cleft lip with or without palate.nMethods: A total of 98 parental pairs of nonsyndromic unilateral incompletencleft lip children, 207 parental pairs of nonsyndromic complete cleft lip andnpalate children, and 206 normal persons from Sichuan University were involvednin this study.A conventional cephalometric analysis was used to measurenangles, linear distances, and their ratios.Two-sample Student’s t tests and anmultivariate discriminant analysis were applied to the data.nResults: Data indicate that the unaffected parents of nonsyndromic cleft lipnchildren had on average significantly more acute cranial base angle (Angle N-S-nBa) and larger nasal width (NC-NC9)(p , .01). The healthy parents of non-nsyndromic cleft lip and palate children consistently displayed a more acutencranial base angle (Angle N-S-Ba), shorter palatal length (A- PNS) and maxillarynlength (PNS-ANS), a more obtuse gonial angle (Angle Me-Go-Ar), and a larger y-naxis length (S-Gn) and nasal width (NC-NC9)(p , .01).nConclusions: All these results indicate that the healthy parents of patientsnwith nonsyndromic cleft lip with or without palate show distinct characteristicsnin craniofacial morphology.These parental craniofacial features are morenobvious in patients with cleft lip with palate than those with cleft lip only.Inngeneral, the characteristics seem to be more distinct in the fathers than in thenmothers of cleft patients.