Chromatographic Properties of a “Comb-like” Chiral Stationary Phase Prepared via Atom Transfer Radical Polymerization

摘要

A “comb-like” chiral stationary phase was developed using surface-initiated technique via atom transfer radical polymerization (ATRP). Chlorinated silica gel was produced as the ATRP initiator in a one-step reaction with thionyl chloride. This initiation method results in a hydrolytically stable initial Si–C bond for poly(glycidyl methacrylate) (pGMA) chains grafted on the surface of silica gel. β-Cyclodextrin (β-CD) was immobilized on the pGMA chains with ring opening reaction to prepare the chiral stationary phase. This “comb-like” chiral stationary phase with the different pGMA chain length was evaluated by enatioseparation of structurally diverse racemic compounds under reversed-phase high-performance liquid chromatography. The chromatographic results demonstrate the effective chiral separation ability of the new chiral stationary phase.