The effect of thyrotropin receptor antibodies on the proliferation of FRTL-5 cells and the expression of protooncogene c-fos mRNA

摘要

Conclusions These data suggest that the stimu- lation of TRAb-lgG followed by cAMP production and ~3H-thymidine incorporation is related to the induction of c-fos mRNA and, thus, to the growth of FRTL-5 cells. Objective Hyperthyroidism and a diffuse goiter are the main symptoms of graves' disease (GD) as- sociate with autoantibodies to thyroid-stimulating hor- mone (TSH) receptor (TRAb). The present study was conducted to evaluate effects of autoantibodies in pa- tients with GD (TRAb-lgG) on induction of the prolifer- ation and c-fos mRNA expression in FRTL-5 cells (Fisher rat thyroid cell line).