Hla-drb1 genes in 5 rheumatic disease multi-case families

摘要

Conclusions Dr4 is closely related to rheuma- toid arthritis. The nelatives of RA patients may be at greater risk to develop RA than individuals without fami- ly history. Some patients and the same DRB1 allele but developed different rheumatic diseases. This suggest- ed that there might be some common pathways in genetic predisposing of rheumatic diseases. On the othe hand, only a few patients with the same DRB1 allele developed rheumatic diseases during their life, so other factors besides DRB1 gene might also be in- volved in the pathogenesis of rheumatic diseases. Objective To detect HLA-DRB1 (DR1-10) alleles in 5 families with multi-case rheumatic diseases, and to study the possible influence of DRB1 genes in the pathogenesis of rheumatic diseased.