Protective effects of vitamin B_(12) , ginseng saponin, and folic acid against murine fetal deformities caused by hyperthermia

摘要

Objective To investigate the protective effects of vitamin B_(12), ginseng saponin, and folic acid on mouse embryos subjected to high heat. Methods Mice were used for the experiment. Results After exposure of pregnant mice to high heat, the rates of teratism, stillbirth, and fetal absorption were markedly lower in mice treated with ginseng saponin and folic acid following heat exposure than in untreated mice. There were no significant differences in these rates when comparing mice treated with vitamin B_(12) with the untreated mice. Conclusions Ginseng saponin and folic acid can lessen injuries to murine embryos caused by high heat, while vitamin B_(12) has little protective effect against high temperature except for promoting overall embryonic growth.